I016 Extracellular matrix remodelling in abdominal aortic aneurysm: involvement of LOXL2 and TG2 reticulation enzymes
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چکیده
منابع مشابه
Drug Therapy for Small Abdominal Aortic Aneurysm
Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
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BACKGROUND Abdominal aortic aneurysm (AAA) has a multifactorial etiology and the relevance of genetic factors is getting increasing interest, in particular those related to the destructive remodeling of extracellular matrix. METHODS We performed a candidate gene association study of polymorphisms in genes coding matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), and elastin ...
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Background and purpose: Abdominal aortic aneurysms (AAA) is a localized enlargement of infrarenal abdominal aorta. Endovascular aneurysm repair (EVAR) is a surgical method introduced for AAA repair. This study, for the first time in Iran, investigated the complications and mortality rate associated with EVAR. Materials and methods: In this cross-sectional study, medical records were reviewed...
متن کاملExtracellular matrix: Composition and Remodelling
Introduction The extracellular matrix is a network of proteins and carbohydrates that supports and surrounds the cells in connective tissues. In addition to their structural-mechanical functions ECM molecules regulate diverse cellular functions, and play a significant role in several physiological and pathological processes, such as embryonic development, inflammation and wound healing, hemosta...
متن کاملExtracellular Matrix Remodelling in Copd
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that involves major remodelling of cells and tissue in the lung. There has been much focus on the inflammatory response, while less attention has been paid to structural changes and alterations of the extracellular matrix (ECM). In this review we revisit some of the latest findings on what is currently known about EC...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases
سال: 2009
ISSN: 1875-2136
DOI: 10.1016/s1875-2136(09)72350-2